Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365418 | 0.88 | CLK2 (0.39) | CLK2LRRK2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19670146 | 0.87 | TSHR (0.45) | TSHRGRM5TP53GAASMN1; SMN2 | |
| SCHEMBL19670228 | 0.85 | NPC1 (0.38) | ALDH1A1HPGDTSHRGRM5SMN1; SMN2 | |
| SCHEMBL17618429 | 0.84 | LRRK2 (0.40) | CLK2LRRK2GRM5TP53GAA | |
| SCHEMBL19670593 | 0.79 | JAK1 (0.38) | CNR1 | |
| SCHEMBL19365904 | 0.77 | MAPT (0.43) | ALDH1A1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19670590 | 0.77 | IRAK4 (0.41) | FGFR1KDRABL1 | |
| SCHEMBL19365708 | 0.77 | MAPT (0.41) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL19365254 | 0.76 | HTR2C (0.47) | TSHRTP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19365744 | 0.76 | ABL1 (0.43) | ALDH1A1TSHRTP53SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |