Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.85 | MAPT (0.43) | KMT2AMEN1ALDH1A1MAPTMCHR1 | |
| SCHEMBL19365256 | 0.85 | RAF1 (0.37) | KMT2AMEN1ALDH1A1ADORA2AKDM1A | |
| SCHEMBL16775899 | 0.84 | ADORA2A (0.38) | KMT2AMEN1ALDH1A1ADORA2AKDM1A | |
| SCHEMBL17618419 | 0.84 | KMT2A (0.42) | KMT2AMEN1ALDH1A1ADORA2AMAPT | |
| SCHEMBL19365708 | 0.83 | MAPT (0.41) | KMT2AMEN1ALDH1A1ADORA2AMAPT | |
| SCHEMBL19365368 | 0.83 | TRPA1 (0.38) | KMT2AMEN1ALDH1A1ADORA2AMAPT | |
| SCHEMBL19365568 | 0.83 | RHOA (0.50) | KMT2AMEN1ALDH1A1MAPTKDM1A | |
| SCHEMBL19670243 | 0.83 | KDM1A (0.38) | KMT2AMEN1ALDH1A1ADORA2AMAPT | |
| SCHEMBL19365596 | 0.83 | ADORA2A (0.39) | KMT2AMEN1ALDH1A1ADORA2AMAPT | |
| SCHEMBL19670489 | 0.82 | CA2 (0.39) | KMT2AMEN1KDM1ATSHRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |