Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365425 | 0.92 | MCHR1 (0.45) | MAPTMCHR1GRIN2BSMN1; SMN2MEN1 | |
| SCHEMBL19365420 | 0.90 | MCHR1 (0.46) | MAPTMCHR1GRIN2BSMN1; SMN2MEN1 | |
| SCHEMBL19365904 | 0.88 | MAPT (0.43) | MAPTMCHR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19365254 | 0.84 | HTR2C (0.47) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL19365708 | 0.84 | MAPT (0.41) | MAPTMCHR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19365568 | 0.84 | RHOA (0.50) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL19670464 | 0.83 | MAPT (0.40) | MAPTMCHR1GRIN2BSMN1; SMN2MEN1 | |
| SCHEMBL19365595 | 0.82 | MAPT (0.38) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL19670411 | 0.81 | MAPT (0.41) | MAPTSMN1; SMN2LMNAHTTNPC1 | |
| SCHEMBL19365368 | 0.81 | TRPA1 (0.38) | MAPTMCHR1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |