Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.87 | MAPT (0.43) | CA2CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19365708 | 0.86 | MAPT (0.41) | CA2CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17618762 | 0.85 | CA2 (0.40) | CA2CA9MAPTALDH1A1HPGD | |
| SCHEMBL19365254 | 0.83 | HTR2C (0.47) | MAPTSMN1; SMN2NPC1TRPV1CYP1A2 | |
| SCHEMBL19365595 | 0.83 | MAPT (0.38) | CA2CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19365360 | 0.82 | CA2 (0.38) | CA2CA9MAPTALDH1A1HPGD | |
| SCHEMBL19670418 | 0.81 | MPL (0.42) | CA2CA9MAPT | |
| SCHEMBL19670411 | 0.80 | MAPT (0.41) | CA2CA9MAPTALDH1A1HPGD | |
| SCHEMBL19365368 | 0.80 | TRPA1 (0.38) | CA2CA9MAPTALDH1A1JAK2 | |
| SCHEMBL19365568 | 0.80 | RHOA (0.50) | MAPTALDH1A1LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |