Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | WNT1 | P04628 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12346827 | 0.80 | L3MBTL1 (0.45) | DYRK1AWNT1ALDH1A1SMN1; SMN2CLK2 | |
| SCHEMBL3563691 | 0.79 | METAP2 (0.47) | ALDH1A1POLBCYP2D6CYP2C9METAP2 | |
| SCHEMBL2238993 | 0.78 | NCF1 (0.62) | DYRK1AALDH1A1SMN1; SMN2MCHR1HRH3 | |
| SCHEMBL15513484 | 0.78 | HRH3 (0.60) | ALDH1A1MCHR1HRH3HDAC1HDAC8 | |
| SCHEMBL2108519 | 0.77 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2POLBHRH3GAA | |
| SCHEMBL1936053 | 0.76 | NCF1 (0.54) | ALDH1A1MCHR1HRH3HDAC1HDAC8 | |
| SCHEMBL1936180 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SIGMAR1MCHR1CYP2D6CYP2C9 | |
| SCHEMBL30340989 | 0.75 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2POLBCYP2D6HRH3 | |
| SCHEMBL15587428 | 0.73 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HRH3GAAHTT | |
| SCHEMBL1936493 | 0.73 | PRMT6 (0.61) | ALDH1A1SMN1; SMN2POLBHRH3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010020556-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | DYRK1A 1636/4885WNT1 2371/4885ALDH1A1 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.