Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | PARG | Q86W56 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TAF1 | P21675 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613034 | 0.77 | ADORA2A (0.46) | CYP1A2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL13384603 | 0.68 | ATAD2 (0.41) | CYP1A2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL24559423 | 0.67 | OPRM1 (0.38) | CYP1A2ADORA2BADORA2ABRD4TAF1 | |
| SCHEMBL30275449 | 0.65 | ADORA2A (0.43) | CYP1A2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL17737315 | 0.63 | ADORA2B (1.00) | CYP1A2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL30275438 | 0.61 | PDE4A (0.43) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL8317662 | 0.61 | RXFP1 (0.45) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL15228294 | 0.61 | ADORA2B (0.47) | CYP1A2ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL30275447 | 0.60 | PIK3CD (0.46) | CYP1A2ADORA2BADORA2A | |
| SCHEMBL30275441 | 0.60 | ADORA3 (0.51) | ADORA2BBRD4ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221177-B2 | Inhibiting the transient receptor potential A1 ion channel | HYDRA BIOSCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170275285-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | ELI LILLY AND COMPANY | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221177-B2 | Inhibiting the transient receptor potential A1 ion channel | TRPV1, TRPA1, TRPV2 | CYP1A2 1655/4885ADORA2B 142/4885ADORA2A 159/4885 |
| US-20170275285-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | TRPV1, TRPA1, TRPV2 | CYP1A2 1655/4885ADORA2B 142/4885ADORA2A 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.