SCHEMBL194516

SCHEMBL194516

Cn1c2c[c]ccc2c2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.64
KDM4E B2RXH2 6/20 0.44
MAPT P10636 5/20 0.44
ALDH1A1 P00352 3/20 0.44
HPGD P15428 3/20 0.44
HSD17B10 Q99714 2/20 0.44
HTT P42858 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ALKBH5 Q6P6C2 1/20 0.44
FTO Q9C0B1 1/20 0.44
KIF11 P52732 1/20 0.43
BCHE P06276 4/20 0.40
ACHE P22303 4/20 0.40
NPC1 O15118 1/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
PABPC1 P11940 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL975434 0.89 GPR3 (0.44) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL193899 0.88 GPR3 (0.64) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL29461528 0.80 GPR3 (1.00) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL29321 0.80 GPR3 (1.00) GPR3KDM4EMAPTALDH1A1HPGD
Hydrochloric Acid SCHEMBL31174327 0.78 GPR3 (0.94) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL18381839 0.78 GPR3 (0.94) GPR3KDM4EMAPTALDH1A1HPGD
Benzene SCHEMBL28231297 0.78 GPR3 (0.94) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL2183525 0.77 KDM4E (0.41) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL975060 0.76 GPR3 (0.44) GPR3KDM4EMAPTALDH1A1HPGD
SCHEMBL9776455 0.76 ALDH1A1 (0.55) KDM4EMAPTALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 298 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116554104-A Indenone and indazolone derivatives with antioxidant activity, and synthetic method and application thereof 西南大学 2023-08-08 CN claimed
CN-116143602-A Indenone and indazolone derivatives with antioxidant activity, and synthetic method and application thereof 西南大学 2023-05-23 CN claimed
US-9249244-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2016-02-02 US claimed
US-8652752-B2 Sulphonium salt initiators BASF SE (DE) 2014-02-18 US claimed
EP-2197840-B1 SULPHONIUM SALT INITIATORS BASF SE (DE) 2013-11-06 EP claimed
CN-102906093-A Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders EUROSCREEN SA 2013-01-30 CN claimed
US-20110166132-A1 Gamma Secretase Modulators AMGEN INC. (US) 2011-07-07 US claimed
US-20100297540-A1 SULPHONIUM SALT INITIATORS BASF SE (DE) 2010-11-25 US claimed
EP-2231602-A1 GAMMA SECRETASE MODULATORS Amgen, Inc (US) 2010-09-29 EP claimed
EP-2197869-A1 SULPHONIUM SALT INITIATORS BASF SE (DE) 2010-06-23 EP claimed
US-7671138-B2 Polymers functionized with hydrobenzamides BRIDGESTONE CORPORATION (JP) 2010-03-02 US claimed
WO-2009075874-A1 GAMMA SECRETASE MODULATORS AMGEN INC. (US) 2009-06-18 WO claimed
WO-2009047105-A1 SULPHONIUM SALT INITIATORS BASF SE (CH) 2009-04-16 WO claimed
US-20070276122-A1 Polymers functionalized with hydrobenzamides BRIDGESTONE CORPORATION 2007-11-29 US claimed
US-20070276098-A1 Polymers functionalized with hydrobenzamide BRIDGESTONE CORPORATION 2007-11-29 US claimed
EP-4053095-B1 METHOD FOR PRODUCING SODIUM SALT OF PHENOLIC COMPOUND AND BISPHOSPHITE COMPOUND MITSUBISHI CHEM CORP (JP) 2024-07-10 EP disclosed
CN-118251380-A Spiro- (indan-fluorene) compounds and their use in organic electronic devices 多蒂肯独家合成控股公司 2024-06-25 CN disclosed
EP-0839623-A1 Stabiliser combination for rotomolding process Ciba SC Holding AG (CH) 1998-05-06 EP disclosed
CN-1177350-A Imidazole derivatives and pharmaceutical compositions thereof YAMANOUCHI PHARMA CO LTD (JP) 1998-03-25 CN disclosed
US-5516920-A POLYMER STABILIZERS CIBA-GEIGY CORPORATION (US) 1996-05-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100297540-A1 SULPHONIUM SALT INITIATORS SULT1A1, SULT2A1, NCOA1 GPR3 1378/4885KDM4E 3933/4885MAPT 1627/4885
US-20110166132-A1 Gamma Secretase Modulators BACE1, BACE2, PSEN1 GPR3 1690/4885KDM4E 2860/4885MAPT 173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.