Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | EYA2 | O00167 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567960 | 0.92 | CHRM2 (0.37) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL438113 | 0.92 | TDP1 (0.58) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL29484958 | 0.92 | CA14 (0.38) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL992084 | 0.92 | TDP1 (0.58) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL4621864 | 0.92 | TDP1 (0.58) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL13635956 | 0.90 | TDP1 (0.35) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL13787056 | 0.90 | TDP1 (0.35) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL15178401 | 0.90 | TDP1 (0.35) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL24896787 | 0.90 | NR1D1 (0.33) | TDP1KDM4EALOX15BLMPMP22 | |
| SCHEMBL7564036 | 0.89 | NR1D1 (0.36) | TDP1KDM4EALOX15BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9855338-B2 | Polyglutamate-amino acid conjugates and methods | NITTO DENKO CORPORATION (JP) | 2018-01-02 | — | — | US | disclosed |
| US-20170119889-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORPORATION (JP) | 2017-05-04 | — | — | US | disclosed |
| US-20170119889-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORPORATION (JP) | 2017-05-04 | — | — | US | disclosed |
| EP-2155255-B1 | Compositions that include a hydrophobic compound and a polyamino acid conjugate | NITTO DENKO CORP (JP) | 2013-08-14 | — | — | EP | disclosed |
| US-8329199-B2 | Compositions that include a hydrophobic compound and a polyamino acid conjugate | NITTO DENKO CORPORATION (JP) | 2012-12-11 | — | — | US | disclosed |
| EP-2125025-B1 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORP (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-20120230917-A1 | COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE | NITTO DENKO CORPORATION (JP) | 2012-09-13 | — | — | US | disclosed |
| US-20120189554-A1 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2012-07-26 | — | — | US | disclosed |
| US-20120189554-A1 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2012-07-26 | — | — | US | disclosed |
| US-8197828-B2 | Compositions that include a hydrophobic compound and a polyamino acid conjugate | NITTO DENKO CORPORATION (JP) | 2012-06-12 | — | — | US | disclosed |
| US-20080279782-A1 | POLYMERS CONJUGATED WITH PLATINUM DRUGS | NITTO DENKO CORPORATION (JP) | 2008-11-13 | — | — | US | disclosed |
| US-20080279782-A1 | POLYMERS CONJUGATED WITH PLATINUM DRUGS | NITTO DENKO CORPORATION (JP) | 2008-11-13 | — | — | US | disclosed |
| WO-2008124735-A2 | MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2008-10-16 | — | — | WO | disclosed |
| US-20080253969-A1 | MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2008-10-16 | — | — | US | disclosed |
| US-20080253969-A1 | MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2008-10-16 | — | — | US | disclosed |
| WO-2008094834-A2 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2008-08-07 | — | — | WO | disclosed |
| US-20080181852-A1 | Multi-functional Drug Carriers | NITTO DENKO CORPORATION (JP) | 2008-07-31 | — | — | US | disclosed |
| WO-2007067417-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORPORATION (JP) | 2007-06-14 | — | — | WO | disclosed |
| US-20070128118-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORPORATION (JP) | 2007-06-07 | — | — | US | disclosed |
| US-20070128118-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORPORATION (JP) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080253969-A1 | MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS | CD44, SGTA, IDUA | TDP1 1203/4885KDM4E 2783/4885ALOX15 4502/4885 |
| US-20120230917-A1 | COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE | SLC7A1, MSN, CD44 | TDP1 2615/4885KDM4E 4480/4885ALOX15 3275/4885 |
| US-20070128118-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | FOLH1, SLC7A1, SLC3A2 | TDP1 1214/4885KDM4E 3657/4885ALOX15 4524/4885 |
| US-20080181852-A1 | Multi-functional Drug Carriers | SLC7A1, SLC19A1, SLC43A1 | TDP1 2536/4885KDM4E 3214/4885ALOX15 4052/4885 |
| US-20170119889-A1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | FOLH1, SLC7A1, SLC3A2 | TDP1 1214/4885KDM4E 3657/4885ALOX15 4524/4885 |
| US-20080279782-A1 | POLYMERS CONJUGATED WITH PLATINUM DRUGS | FOLR1, PAICS, ABCC1 | TDP1 1403/4885KDM4E 4654/4885ALOX15 3815/4885 |
| US-20120189554-A1 | MULTI-FUNCTIONAL DRUG CARRIERS | SLC7A1, SLC19A1, SLC43A1 | TDP1 2536/4885KDM4E 3214/4885ALOX15 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.