Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 5/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464241 | 0.85 | LMNA (0.39) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL27215222 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL31248171 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL29705440 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL29705852 | 0.85 | LMNA (0.39) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL29705484 | 0.81 | CYP4F2 (0.42) | ALDH1A1LMNAPOLBYTHDC1CYP4F2 | |
| SCHEMBL16793799 | 0.81 | CYP4F2 (0.42) | ALDH1A1LMNAPOLBYTHDC1CYP4F2 | |
| SCHEMBL31585725 | 0.80 | LMNA (0.45) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL1128620 | 0.79 | CYP2C19 (0.41) | ALDH1A1LMNAPOLBRETYTHDC1 | |
| SCHEMBL19464063 | 0.79 | RXRA (0.46) | ALDH1A1LMNAPOLBRETYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442945-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2020-07-08 | — | — | EP | disclosed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2019-08-06 | — | — | US | disclosed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | disclosed |
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2019-04-11 | — | — | US | disclosed |
| EP-3442945-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SPRL (BE) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | disclosed |
| WO-2017178377-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106406-A1 | Tetrahydroisoquinoline Derivatives | GPR52, GRK3, GPR3 | ALDH1A1 1311/4885LMNA 4378/4885POLB 3242/4885 |
| US-10370355-B2 | Tetrahydroisoquinoline derivatives | GPR52, GRK3, GPR3 | ALDH1A1 1311/4885LMNA 4378/4885POLB 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.