Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.73 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.72 |
| ▸ | NAMPT | P43490 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.63 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571386 | 0.89 | LMNA (1.00) | LMNAHIF1AROCK2ROCK1NAMPT | |
| Nicotinanilide SCHEMBL352439 | 0.84 | LMNA (0.83) | LMNAHIF1AROCK2ROCK1NAMPT | |
| SCHEMBL14880208 | 0.84 | ROCK2 (1.00) | LMNAHIF1AROCK2ROCK1NAMPT | |
| Nicotinanilide SCHEMBL29067673 | 0.84 | LMNA (0.83) | LMNAHIF1AROCK2ROCK1NAMPT | |
| SCHEMBL4243217 | 0.84 | BCAT2 (1.00) | LMNAHIF1ABCAT2NAMPTKCNK3 | |
| SCHEMBL1971026 | 0.83 | NAMPT (0.78) | LMNAHIF1AROCK2ROCK1NAMPT | |
| Nicotinanilide SCHEMBL8155304 | 0.83 | LMNA (0.81) | LMNAHIF1AROCK2ROCK1NAMPT | |
| SCHEMBL5384036 | 0.81 | ROCK2 (0.76) | LMNAHIF1AROCK2ROCK1NAMPT | |
| SCHEMBL26429188 | 0.81 | LMNA (0.71) | LMNAHIF1AROCK2ROCK1NAMPT | |
| SCHEMBL167081 | 0.81 | NAMPT (1.00) | LMNAHIF1ABCAT2NAMPTKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017186148-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS | ASTAR BIOTECH LLC (US) | 2017-11-02 | — | — | WO | disclosed |