Nicotinanilide

Nicotinanilide

SCHEMBL8155304

Cl.O=C(Nc1ccccc1)c1cccnc1

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Nicotinanilide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 known ✓ O14649 1/20 0.79
ROCK2 known ✓ O75116 1/20 0.78
ROCK1 known ✓ Q13464 1/20 0.78
GAA known ✓ P10253 1/20 0.65
JAK2 known ✓ O60674 1/20 0.64
LMNA P02545 2/20 0.81
HIF1A Q16665 1/20 0.81
NAMPT P43490 3/20 0.78
ALDH1A1 P00352 2/20 0.68
RAB9A P51151 5/20 0.66
NPC1 O15118 4/20 0.66
SMN1; SMN2 Q16637 3/20 0.66
KMT2A Q03164 2/20 0.66
MEN1 O00255 1/20 0.66
TP53 P04637 1/20 0.66
TDP1 Q9NUW8 1/20 0.65
CYP3A4 P08684 1/20 0.64
HTT P42858 1/20 0.64
TYK2 P29597 1/20 0.64
PIM1 P11309 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nicotinanilide SCHEMBL352439 0.98 LMNA (0.83) LMNAHIF1AKCNK3NAMPTROCK2
Nicotinanilide SCHEMBL29067673 0.98 LMNA (0.83) LMNAHIF1AKCNK3NAMPTROCK2
Nicotinanilide SCHEMBL27369687 0.92 LMNA (0.73) LMNAHIF1AKCNK3NAMPTROCK2
Hydrochloric Acid SCHEMBL27890956 0.90 NAMPT (0.97) LMNAHIF1AKCNK3NAMPTRAB9A
SCHEMBL1571386 0.89 LMNA (1.00) LMNAHIF1AKCNK3NAMPTROCK2
Nicotinanilide SCHEMBL27980002 0.89 LMNA (0.69) LMNAHIF1AKCNK3NAMPTROCK2
SCHEMBL167081 0.88 NAMPT (1.00) LMNAHIF1AKCNK3NAMPTRAB9A
SCHEMBL14880208 0.88 ROCK2 (1.00) LMNAHIF1AKCNK3NAMPTROCK2
SCHEMBL7329481 0.87 ROCK2 (0.73) LMNAHIF1AKCNK3NAMPTROCK2
Hydrochloric Acid SCHEMBL2105310 0.86 KCNK3 (0.78) LMNAHIF1AKCNK3NAMPTROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106083712-B A kind of synthetic method of nicotinanilide salt 王正友 2018-10-16 CN claimed
CN-101715786-B Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLOGY DEV CO LTD 2012-07-25 CN claimed
CN-101715786-A Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLO 2010-06-02 CN claimed
CN-1205862-C Snailkilling chemical for aquiculture WANG ZHENGYOU (CN) 2005-06-15 CN claimed
EP-2905361-B1 METHOD OF FORMING A METAL COATING TOYOTA MOTOR CO LTD (JP) 2022-01-05 EP disclosed
CN-106083712-B A kind of synthetic method of nicotinanilide salt 王正友 2018-10-16 CN disclosed
EP-3170789-B1 PRODUCTION PROCESS FOR FLUOROSULFONYLIMIDE AMMONIUM SALT NIPPON SODA CO (JP) 2018-04-18 EP disclosed
US-9708723-B2 Electroplating cell, and metal coating and method of forming the same TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) 2017-07-18 US disclosed
EP-3170789-A1 PRODUCTION PROCESS FOR FLUOROSULFONYLIMIDE SALT NIPPON SODA CO., LTD. (JP) 2017-05-24 EP disclosed
CN-106083712-A A kind of synthetic method of nicotinanilide salt 王正友 2016-11-09 CN disclosed
US-9242862-B2 Process for production of fluorosulfonylimide ammonium salt NIPPON SODA CO., LTD. (JP) 2016-01-26 US disclosed
EP-2905361-A1 ELECTROPLATING CELL, METAL COATING AND METHOD OF FORMING THE SAME Toyota Jidosha Kabushiki Kaisha (JP) 2015-08-12 EP disclosed
CN-101715786-B Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLOGY DEV CO LTD 2012-07-25 CN disclosed
CN-101715786-B Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLOGY DEV CO LTD 2012-07-25 CN disclosed
CN-101715786-A Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLO 2010-06-02 CN disclosed
CN-101715786-A Molluscicide for aquiculture and preparation method thereof WUHAN XINGWANG BIOLOG TECHNOLO 2010-06-02 CN disclosed
CN-1205862-C Snailkilling chemical for aquiculture WANG ZHENGYOU (CN) 2005-06-15 CN disclosed
CN-1437851-A Snailkilling chemical for aquiculture WANG ZHENGYOU (CN) 2003-08-27 CN disclosed
US-6121386-A A SURFACE COATING TO IMPROVE OLEFIN RESIN FILMS COATABILITY E.G., ADHESION, COMPRISING A BLEND OF EPOXIDIZED BLOCK COPOLYMER OF AN AROMATIC VINYL COMPOUND AND A CONJUGATED DIENE, AND A POLYMER WITH A REACTIVE FUNCTIONAL GROUP DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-19 US disclosed
EP-0879861-A1 RESIN COMPOSITIONS FOR COATING DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-25 EP disclosed