Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16144645 | 0.84 | HSD11B1 (0.50) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL17518824 | 0.80 | CYP11B2 (0.54) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL14035863 | 0.78 | HSD11B1 (0.57) | HSD11B1CYP11B2SPRRAB9AALDH1A1 | |
| SCHEMBL17516264 | 0.77 | HSD11B1 (0.50) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL24059287 | 0.75 | CYP11B2 (0.57) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL31339129 | 0.74 | GPR119 (0.56) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL25274630 | 0.74 | GPR119 (0.56) | HSD11B1PRMT5WDR77CYP11B2SPR | |
| SCHEMBL26177473 | 0.74 | ALDH1A1 (0.50) | HSD11B1PRMT5WDR77SPRRAB9A | |
| SCHEMBL14276850 | 0.74 | HSD11B1 (0.60) | HSD11B1CYP11B2SPRKDM4EBLM | |
| SCHEMBL17779065 | 0.72 | CYP11B2 (0.57) | CYP11B2ALDH1A1CHRNA7CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |