Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763133 | 0.78 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP2A6GAALMNA | |
| SCHEMBL4521095 | 0.72 | CYP1A2 (0.48) | ALDH1A1CYP1A2CYP2A6SIGMAR1GAA | |
| Ethylbenzene SCHEMBL6209262 | 0.72 | TP53 (0.64) | ALDH1A1CYP1A2CYP2A6TP53LMNA | |
| SCHEMBL4516955 | 0.69 | CYP1A2 (0.48) | ALDH1A1CYP1A2CYP2A6TP53SIGMAR1 | |
| SCHEMBL7714016 | 0.69 | MAPT (0.36) | ALDH1A1CYP1A2CYP2A6SIGMAR1POLB | |
| Propane SCHEMBL27921273 | 0.69 | ALDH1A1 (0.82) | ALDH1A1CYP1A2LMNAMAPTKMT2A | |
| SCHEMBL4514411 | 0.68 | HTR7 (0.41) | ALDH1A1CYP1A2CYP2A6TP53GAA | |
| SCHEMBL1486001 | 0.68 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2A6GAALMNA | |
| SCHEMBL320706 | 0.68 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2A6TP53SIGMAR1 | |
| SCHEMBL1058699 | 0.67 | CYP1A2 (0.46) | ALDH1A1CYP1A2CYP2A6TP53SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197046-A1 | C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |
| WO-2017197036-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |