Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB1 | Q9Y478 | 8/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19611358 | 0.86 | PRKAB1 (0.41) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL19611343 | 0.84 | BMPR1B (0.42) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16026085 | 0.76 | RET (0.58) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16111465 | 0.75 | PRKAB1 (0.52) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL17442241 | 0.75 | PRKAB1 (0.59) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16112488 | 0.74 | PRKAB1 (0.53) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL28406942 | 0.74 | ACVR1 (0.42) | ACVR1TGFBR1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL29252729 | 0.73 | AGTR2 (0.48) | SLC6A7 | |
| SCHEMBL17531601 | 0.72 | PRKAB1 (0.62) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL25205245 | 0.72 | RET (0.44) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | BMP1, BMPR2, BMP2 | PRKAB1 3076/4885PRKAB2 3101/4885PRKAG1 3344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.