Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 2/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21098120 | 0.81 | NOS3 (0.33) | ACHECCR1CCR5CCR8 | |
| SCHEMBL14041762 | 0.80 | UHRF1 (0.46) | UHRF1DYRK1AROCK2ROCK1SMARCA2 | |
| SCHEMBL11075725 | 0.79 | UHRF1 (0.50) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL19992429 | 0.79 | LOX (0.44) | DYRK1AROCK2ACHECCR1CCR5 | |
| SCHEMBL17198732 | 0.78 | UHRF1 (0.48) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL19846691 | 0.78 | UHRF1 (0.48) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL22854174 | 0.77 | UHRF1 (0.39) | UHRF1DYRK1AROCK2ROCK1SMARCA2 | |
| SCHEMBL20247131 | 0.76 | UHRF1 (0.46) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL23727271 | 0.75 | LOXL2 (0.41) | SMARCA2SMARCA4HDAC4 | |
| SCHEMBL27045873 | 0.75 | KDM5A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334917-A1 | PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE | HAMP, SERPINC1, PRSS8 | UHRF1 3117/4885DYRK1A 4818/4885ROCK2 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.