Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | NAAA | Q02083 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2089333 | 0.66 | DDB1 (0.45) | DDB1CRBNSMN1; SMN2CA2NAAA | |
| SCHEMBL27914349 | 0.65 | CALM1 (0.68) | SMN1; SMN2MEN1ALDH1A1LMNAGAA | |
| SCHEMBL145761 | 0.65 | LTA4H (0.52) | SMN1; SMN2CA2TP53HTR2ACA1 | |
| SCHEMBL6558445 | 0.65 | ALDH1A1 (0.54) | SMN1; SMN2CA2NPC1TSHRRAB9A | |
| SCHEMBL83869 | 0.64 | CA2 (0.65) | SMN1; SMN2CA2TP53SKP2HTR2A | |
| SCHEMBL16933991 | 0.63 | LMNA (0.62) | SMN1; SMN2TSHRMEN1ALDH1A1LMNA | |
| SCHEMBL145506 | 0.63 | CALM1 (0.64) | SMN1; SMN2MEN1ALDH1A1LMNAGAA | |
| SCHEMBL111607 | 0.62 | GFER (0.62) | SMN1; SMN2CA2NPC1TP53TSHR | |
| SCHEMBL13348593 | 0.62 | POLB (0.50) | SMN1; SMN2CA2NPC1TP53RAB9A | |
| SCHEMBL5614714 | 0.62 | LTA4H (0.66) | TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793884-B1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2017-11-29 | — | — | EP | disclosed |