SCHEMBL196559

SCHEMBL196559

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.87

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NT5E P21589 4/20 0.87
TGM2 P21980 1/20 0.78
KRAS P01116 5/20 0.70
P2RX3 P56373 2/20 0.70
ALDH1A1 P00352 1/20 0.70
P2RX1 P51575 1/20 0.70
FUT5 Q11128 1/20 0.69
P2RY1 P47900 1/20 0.69
P2RY2 P41231 1/20 0.64
P2RY4 P51582 1/20 0.64
P2RY6 Q15077 1/20 0.64
DCPS Q96C86 1/20 0.63
ENTPD2 Q9Y5L3 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29941868 1.00 NT5E (0.87) NT5ETGM2KRASP2RX3ALDH1A1
SCHEMBL24409559 1.00 NT5E (0.87) NT5ETGM2KRASP2RX3ALDH1A1
Phosphomethylphosphonic Acid Guanosyl Ester SCHEMBL12714637 0.93 NT5E (1.00) NT5ETGM2KRAS
Phosphomethylphosphonic Acid Guanosyl Ester SCHEMBL4312033 0.93 NT5E (1.00) NT5ETGM2KRAS
Phosphomethylphosphonic Acid Guanosyl Ester SCHEMBL12714656 0.93 NT5E (1.00) NT5ETGM2KRAS
Phosphomethylphosphonic Acid Guanosyl Ester SCHEMBL21067782 0.93 NT5E (1.00) NT5ETGM2KRAS
SCHEMBL21067722 0.93 TGM2 (0.85) NT5ETGM2KRASP2RX3ALDH1A1
SCHEMBL29429843 0.93 TGM2 (0.85) NT5ETGM2KRASP2RX3ALDH1A1
SCHEMBL851357 0.93 TGM2 (0.85) NT5ETGM2KRASP2RX3ALDH1A1
SCHEMBL18769114 0.93 TGM2 (0.85) NT5ETGM2KRASP2RX3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12584916-B2 Method for measuring the modulation of the activation of a G protein-coupled receptor with GTP analogues CISBIO BIOASSAYS (FR) 2026-03-24 US claimed
US-12522656-B2 Anti-G-protein alpha antibody CISBIO BIOASSAYS (FR) 2026-01-13 US claimed
US-12492234-B2 Fiber assembly and use thereof KYOTO UNIVERSITY (JP) 2025-12-09 US claimed
EP-3658913-B1 METHOD FOR MEASURING MODULATION IN THE ACTIVITY OF A G PROTEIN-COUPLED RECEPTOR CISBIO BIOASSAYS (FR) 2024-04-03 EP claimed
CN-111164427-B Method for measuring modulation of G protein coupled receptor activity CISBIO生物试验公司 2023-12-19 CN claimed
WO-2023196234-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-12 WO claimed
US-20230310380-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-05 US claimed
WO-2023149801-A1 METHOD FOR PREPARING A CONFORMATION-SPECIFIC ANTIBODY. ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2023-08-10 WO claimed
US-20230135945-A1 Method for Measuring Modulation in the Activity of a G Protein-Coupled Receptor CISBIO ASSAYS (FR) 2023-05-04 US claimed
US-20230091315-A1 ANTI-G-PROTEIN ALPHA ANTIBODY CISBIO BIOASSAYS (FR) 2023-03-23 US claimed
EP-4097133-A1 ANTI-G-PROTEIN ALPHA ANTIBODY CISBIO BIOASSAYS (FR) 2022-12-07 EP claimed
CN-115397858-A anti-G protein alpha antibody CISBIO生物试验公司 2022-11-25 CN claimed
US-20220099669-A1 METHOD FOR MEASURING THE MODULATION OF THE ACTIVATION OF A G PROTEIN-COUPLED RECEPTOR WITH GTP ANALOGUES CISBIO BIOASSAYS (FR) 2022-03-31 US claimed
US-20260132178-A1 ENGINEERED IMMUNOCYTOKINES, FUSION POLYPEPTIDES, AND IL10 POLYPEPTIDES SYNERKINE PHARMA B V (NL) 2026-05-14 US disclosed
US-12584916-B2 Method for measuring the modulation of the activation of a G protein-coupled receptor with GTP analogues CISBIO BIOASSAYS (FR) 2026-03-24 US disclosed
US-12522656-B2 Anti-G-protein alpha antibody CISBIO BIOASSAYS (FR) 2026-01-13 US disclosed
US-5767278-A ANTICARCINOGENIC AGENTS GERON CORPORATION (US) 1998-06-16 US disclosed
US-5760062-A ANTICANCER AGENTS GERON CORPORATION (US) 1998-06-02 US disclosed
US-5703116-A TREATING CANCER GERON CORPORATION (US) 1997-12-30 US disclosed
US-5656638-A ANTICANCER, ANTITUMOR AGENTS GERON CORPORATION (US) 1997-08-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230091315-A1 ANTI-G-PROTEIN ALPHA ANTIBODY GNG2, GNAI3, GNAI2 NT5E 257/4885TGM2 353/4885KRAS 72/4885
US-20260132178-A1 ENGINEERED IMMUNOCYTOKINES, FUSION POLYPEPTIDES, AND IL10 POLYPEPTIDES IL4, IL2, IL2RA NT5E 2302/4885TGM2 2812/4885KRAS 4427/4885
US-12584916-B2 Method for measuring the modulation of the activation of a G protein-coupled receptor with GTP analogues GNAI1, GNAI3, GNB1 NT5E 1604/4885TGM2 584/4885KRAS 139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.