Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10187266 | 0.81 | HRH4 (0.36) | PYCR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL7526844 | 0.74 | ERN1 (0.34) | CCR5PYCR1APPALDH1A1LMNA | |
| SCHEMBL22272311 | 0.70 | CCR5 (0.48) | CCR5PYCR1APPALDH1A1HTT | |
| SCHEMBL9485990 | 0.70 | CCR5 (0.42) | CCR5PYCR1APPALDH1A1POLB | |
| SCHEMBL9566865 | 0.70 | ALOX15 (0.42) | CCR5PYCR1APPALDH1A1LMNA | |
| SCHEMBL19657347 | 0.69 | NMT1 (0.32) | — | |
| SCHEMBL18228396 | 0.69 | CCR5 (0.41) | CCR5PYCR1APPALDH1A1LMNA | |
| SCHEMBL14808309 | 0.69 | HRH4 (0.41) | CCR5PYCR1APPALDH1A1GAA | |
| SCHEMBL24094415 | 0.68 | HRH4 (0.33) | CCR5PYCR1 | |
| SCHEMBL22339987 | 0.68 | PYCR1 (0.33) | PYCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |