Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19010597 | 0.83 | PDE2A (0.39) | GABRA1GABRG2GABRB3P2RX7RORC | |
| SCHEMBL12313392 | 0.82 | TAAR1 (0.43) | GABRA1P2RX7SLC6A2GABRB2HSD11B1 | |
| SCHEMBL18469082 | 0.80 | GABRA1 (0.62) | GABRA1GABRG2GABRB3SLC6A2CYP1A2 | |
| SCHEMBL11148941 | 0.79 | TAAR1 (0.39) | GABRA1P2RX7SLC6A2HPGDLMNA | |
| SCHEMBL22697021 | 0.78 | PDE2A (0.38) | GABRA1GABRG2GABRB3P2RX7RORC | |
| SCHEMBL22519417 | 0.76 | PDE2A (0.37) | GABRA1GABRG2GABRB3P2RX7RORC | |
| SCHEMBL84477 | 0.76 | P2RX7 (0.50) | GABRA1GABRG2GABRB3P2RX7SLC6A2 | |
| SCHEMBL24911005 | 0.75 | CA2 (0.41) | GABRA1P2RX7SLC6A2CA2TSHR | |
| SCHEMBL5407429 | 0.75 | SLC6A2 (0.43) | P2RX7SLC6A2CYP3A4HSD11B1RORC | |
| SCHEMBL13856265 | 0.75 | TAAR1 (0.39) | GABRA1P2RX7GABRB2TRPV1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661921-B1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NODTHERA LTD (GB) | 2023-10-18 | — | — | EP | disclosed |
| US-20170340610-A1 | RORgammaT INHIBITORS | MERCK SHARP & DOHME LLC | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340610-A1 | RORgammaT INHIBITORS | RORB, RORC, RORA | GABRA1 210/4885GABRG2 138/4885GABRB3 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.