Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.36 |
| ▸ | WNT3A | P56704 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670242 | 0.85 | SLC27A1 (0.35) | ALDH1A1MAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL20733192 | 0.85 | PIK3CA (0.39) | PIK3CAPIK3CDPIK3CBPIK3CGWNT3A | |
| SCHEMBL19670238 | 0.83 | TRPA1 (0.38) | MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19865050 | 0.82 | HTR2C (0.40) | WNT3AALDH1A1MAPT | |
| SCHEMBL19670512 | 0.82 | BTK (0.37) | WNT3AJAK2 | |
| SCHEMBL17618696 | 0.81 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CBPIK3CGWNT3A | |
| SCHEMBL16754546 | 0.80 | PIK3CD (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGWNT3A | |
| SCHEMBL19669734 | 0.79 | MAT2A (0.40) | WNT3AHTT | |
| SCHEMBL19670405 | 0.77 | BRAF (0.40) | WNT3A | |
| SCHEMBL19670135 | 0.77 | MEN1 (0.41) | ALDH1A1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |