Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670238 | 0.85 | TRPA1 (0.38) | TRPV3SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL19669970 | 0.85 | PIK3CA (0.36) | SMN1; SMN2MAPTALDH1A1HTTNPSR1 | |
| SCHEMBL16775986 | 0.83 | SLC27A1 (0.36) | SLC27A1TRPV3SMN1; SMN2POLQCARM1 | |
| SCHEMBL17618488 | 0.83 | POLQ (0.38) | SLC27A1TRPV3KCNK3SMN1; SMN2ALDH1A1 | |
| SCHEMBL19670393 | 0.83 | ABL1 (0.42) | TRPV3SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19670432 | 0.83 | TRPV3 (0.34) | TRPV3CARM1PRMT6PRMT8NPC1 | |
| SCHEMBL16776264 | 0.82 | SLC27A1 (0.35) | SLC27A1TRPV3SMN1; SMN2POLQCARM1 | |
| SCHEMBL19669985 | 0.82 | KARS1 (0.43) | TRPV3CARM1PRMT6PRMT8 | |
| SCHEMBL19670263 | 0.82 | DHFR (0.37) | TRPV3CARM1PRMT6PRMT8NPC1 | |
| SCHEMBL19670389 | 0.80 | ROCK2 (0.35) | TRPV3MAPTPOLQCARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |