Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 3/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | CDK11B | P21127 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670242 | 0.85 | SLC27A1 (0.35) | MAPTSMN1; SMN2NPSR1TRPV3 | |
| SCHEMBL19670590 | 0.83 | IRAK4 (0.41) | TRPA1IRAK4FYNUSP30PIM1 | |
| SCHEMBL19670589 | 0.83 | HTR2C (0.42) | FYNABL1 | |
| SCHEMBL17618473 | 0.83 | GLS (0.39) | TRPA1IRAK4FYNUSP30ABL1 | |
| SCHEMBL19670385 | 0.83 | MPL (0.44) | TRPA1IRAK4FYNUSP30PIM1 | |
| SCHEMBL19670164 | 0.83 | GSK3B (0.40) | IRAK4PIM1BRAFKDR | |
| SCHEMBL19670428 | 0.83 | ABL1 (0.40) | IRAK4FYNPIM1CHRM2STK10 | |
| SCHEMBL19669970 | 0.83 | PIK3CA (0.36) | MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19670257 | 0.82 | HPGDS (0.38) | IRAK4PIM1CDK2KDM4EMAPT | |
| SCHEMBL19670386 | 0.81 | CACNA1H (0.37) | TRPA1IRAK4FYNBRAFFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |