Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | RAF1 | P04049 | 5/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670221 | 0.86 | UBE2M (0.37) | BRAFRAF1MAPTADORA2AMTOR | |
| SCHEMBL19670214 | 0.85 | TRPA1 (0.38) | BRAFRAF1MAPTADORA2ACA2 | |
| SCHEMBL16775891 | 0.84 | BRAF (0.36) | TRPV1BRAFRAF1DGAT2SYK | |
| SCHEMBL17618411 | 0.84 | KIT (0.37) | TRPV1BRAFRAF1DGAT2SYK | |
| SCHEMBL19670580 | 0.83 | TRPV1 (0.43) | TRPV1CA2CA9 | |
| SCHEMBL19670135 | 0.83 | MEN1 (0.41) | TRPV1BRAFRAF1MAPTADORA2A | |
| SCHEMBL19670209 | 0.83 | CNR2 (0.36) | BRAFRAF1MAPTADORA2ACA2 | |
| SCHEMBL19670179 | 0.82 | HTR2C (0.46) | TRPV1BRAF | |
| SCHEMBL19670218 | 0.81 | MAPT (0.43) | TRPV1BRAFRAF1MAPTADORA2A | |
| SCHEMBL19670629 | 0.81 | CA2 (0.40) | TRPV1BRAFRAF1MAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |