Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365522 | 0.88 | KDM4E (0.39) | DYRK1AIRAK4SLC5A1HPGDSFYN | |
| SCHEMBL19670150 | 0.87 | IRAK4 (0.40) | IRAK4GSK3BMAPK14SLC5A1SCN9A | |
| SCHEMBL19670588 | 0.86 | FGFR4 (0.38) | FGFR4FAAHCSNK1DCSNK1EMAPK1 | |
| SCHEMBL17618447 | 0.85 | KIT (0.41) | KDRFGFR4KITFAAHDYRK1A | |
| SCHEMBL19670362 | 0.85 | IRAK4 (0.39) | IRAK4SLC5A1SCN9AFYN | |
| SCHEMBL19670149 | 0.85 | FGFR4 (0.39) | FGFR4KITFAAHCSNK1DCSNK1E | |
| SCHEMBL19670233 | 0.85 | FAAH (0.39) | FGFR4FAAHCSNK1DCSNK1EMAPK1 | |
| SCHEMBL19670584 | 0.85 | FAAH (0.41) | FGFR4FAAHDYRK1AIRAK4CSNK1D | |
| SCHEMBL19670168 | 0.85 | IRAK4 (0.43) | IRAK4GSK3BMAPK14SLC5A1SCN9A | |
| SCHEMBL19365442 | 0.85 | FAAH (0.37) | FGFR4FAAHCSNK1DCSNK1ECCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |