Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 6/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670225 | 0.90 | MLLT1 (0.38) | MLLT1CREBBPNOTUMMCHR1RAF1 | |
| SCHEMBL19670590 | 0.88 | IRAK4 (0.41) | FYNCREBBPBRD4TRPA1IRAK4 | |
| SCHEMBL19670253 | 0.85 | MLLT1 (0.38) | CACNA1HMLLT1CREBBPNOTUMMLLT3 | |
| SCHEMBL19670251 | 0.85 | MLLT1 (0.39) | MLLT1CREBBPNOTUMMLLT3 | |
| SCHEMBL19670589 | 0.85 | HTR2C (0.42) | CACNA1HFYNHTR2A | |
| SCHEMBL17618475 | 0.84 | ABL1 (0.39) | CACNA1HFYNHTR2ACREBBPBRD4 | |
| SCHEMBL19670428 | 0.82 | ABL1 (0.40) | FYNIRAK4 | |
| SCHEMBL19670385 | 0.81 | MPL (0.44) | FYNTRPA1IRAK4 | |
| SCHEMBL19670238 | 0.81 | TRPA1 (0.38) | FYNTRPA1IRAK4RAF1BRAF | |
| SCHEMBL19670164 | 0.81 | GSK3B (0.40) | IRAK4BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |