Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.32 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670234 | 0.89 | FGFR4 (0.35) | FGFR4BRD4 | |
| SCHEMBL19365462 | 0.86 | FGFR4 (0.42) | TRPV1FGFR4PRKCAGSK3BWNT3A | |
| SCHEMBL19670220 | 0.85 | ROCK2 (0.34) | TRPV1MTORTRPV3BRD4 | |
| SCHEMBL17618590 | 0.85 | TRPV1 (0.36) | TRPV1FGFR4PRKCAGSK3BMTOR | |
| SCHEMBL19670484 | 0.84 | FAAH (0.37) | FGFR4MTORWNT3APTK2BRD4 | |
| SCHEMBL19670246 | 0.84 | SCN9A (0.39) | TRPV1FGFR4MTOR | |
| SCHEMBL19670420 | 0.83 | HDAC2 (0.42) | FGFR4MTORBRD4KDM4EALDH1A1 | |
| SCHEMBL19670365 | 0.83 | VCP (0.37) | FGFR4GSK3BTRPV3ABL1 | |
| SCHEMBL19670362 | 0.82 | IRAK4 (0.39) | — | |
| SCHEMBL19365387 | 0.81 | VCP (0.35) | FGFR4PRKCAKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |