Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DLK1 | P80370 | 2/20 | 0.34 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 5/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670226 | 0.91 | CNR2 (0.38) | MAP3K12WNT1GSK3BDYRK1ADLK1 | |
| SCHEMBL19670360 | 0.90 | KARS1 (0.40) | MAP3K12WNT1GSK3BDYRK1ADLK1 | |
| SCHEMBL19670206 | 0.89 | DYRK1A (0.34) | MAP3K12WNT1GSK3BDYRK1ADLK1 | |
| SCHEMBL19365431 | 0.89 | IDH1 (0.34) | MAP3K12CACNA1HWNT1GSK3BDYRK1A | |
| SCHEMBL19365587 | 0.86 | FGFR4 (0.39) | CACNA1HWNT1GSK3BDYRK1ACSF1R | |
| SCHEMBL19670334 | 0.86 | FGFR4 (0.36) | MAP3K12CACNA1HWNT1GSK3BDYRK1A | |
| SCHEMBL19670490 | 0.86 | SLC34A1 (0.36) | MAP3K12WNT1GSK3BDYRK1ACSF1R | |
| SCHEMBL19365654 | 0.86 | HCRTR1 (0.44) | CSF1RMETKDRHCRTR1 | |
| SCHEMBL17618649 | 0.85 | SCD (0.37) | MAP3K12CACNA1HDLK1DRG1SCD | |
| SCHEMBL19365756 | 0.81 | VCP (0.38) | MAP3K12GSK3BDYRK1ADLK1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |