Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631618 | 0.89 | ABL1 (0.36) | FGFR4RAB9AKDM4EABL1CYP11B2 | |
| SCHEMBL19365591 | 0.84 | ABL1 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4RAB9A | |
| SCHEMBL19670348 | 0.82 | CHRNB2 (0.34) | FGFR4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19670496 | 0.82 | MTOR (0.38) | FGFR4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19670124 | 0.82 | WNT3A (0.40) | CYP11B2PORCNCSF1R | |
| SCHEMBL16776155 | 0.81 | ABL1 (0.37) | FGFR4RAB9AKDM4EABL1CYP11B2 | |
| SCHEMBL19699074 | 0.80 | FAAH (0.37) | FGFR4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19670433 | 0.79 | ALOX15 (0.36) | FGFR4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19361181 | 0.74 | ABL1 (0.35) | KDM4EABL1CYP2D6PORCNMAP4K1 | |
| SCHEMBL19670523 | 0.73 | TRPV3 (0.38) | RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |