Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670124 | 0.86 | WNT3A (0.40) | CSF1R | |
| SCHEMBL19670433 | 0.85 | ALOX15 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4FGFR4 | |
| SCHEMBL19365562 | 0.84 | MTOR (0.41) | MTORPIK3R1FAAHGSK3BMLLT1 | |
| SCHEMBL19699074 | 0.84 | FAAH (0.37) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19670344 | 0.82 | FGFR4 (0.35) | FAAHCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16776152 | 0.81 | FAAH (0.35) | FAAHFGFR4GSK3BSIRT2CDK8 | |
| SCHEMBL19670348 | 0.80 | CHRNB2 (0.34) | MTORCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20632999 | 0.78 | JAK2 (0.32) | GSK3BCDK8GSK3ACDK9CDK5 | |
| SCHEMBL20632331 | 0.76 | DYRK1A (0.40) | FAAHFGFR4GSK3BCDK8GSK3A | |
| SCHEMBL17655361 | 0.76 | ROCK2 (0.36) | SMN1; SMN2PRMT3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |