Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 5/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776151 | 0.82 | BRD4 (0.36) | BRD4RAB9ANPC1HDAC6CYP1A2 | |
| SCHEMBL19670344 | 0.82 | FGFR4 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4RAB9A | |
| SCHEMBL19670124 | 0.82 | WNT3A (0.40) | CSF1R | |
| SCHEMBL19670496 | 0.80 | MTOR (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4MTOR | |
| SCHEMBL19699074 | 0.78 | FAAH (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4RAB9A | |
| SCHEMBL19670433 | 0.77 | ALOX15 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL17618639 | 0.76 | CLK4 (0.34) | BRD4RAB9ANPC1HDAC6CYP1A2 | |
| SCHEMBL19670523 | 0.73 | TRPV3 (0.38) | MTORRAB9ANPC1KMT2A | |
| SCHEMBL19706161 | 0.73 | TRPV3 (0.38) | MTORRAB9ANPC1KMT2A | |
| SCHEMBL19365697 | 0.71 | DYRK1A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |