Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670153 | 0.91 | VCP (0.41) | DHFRFAAHJAK2CAMK2DKARS1 | |
| SCHEMBL19670263 | 0.90 | DHFR (0.37) | DHFRFAAHPRKCIJAK2ABL1 | |
| SCHEMBL19365269 | 0.89 | KARS1 (0.45) | DHFRFAAHPRKCIJAK2ABL1 | |
| SCHEMBL19670584 | 0.87 | FAAH (0.41) | FAAHJAK2ABL1CAMK2DTRPV3 | |
| SCHEMBL19670365 | 0.87 | VCP (0.37) | JAK2ABL1TRPV3GSK3BDYRK1A | |
| SCHEMBL19670418 | 0.86 | MPL (0.42) | FAAHAR | |
| SCHEMBL19365744 | 0.85 | ABL1 (0.43) | JAK2ABL1BCRCAMK2DTEK | |
| SCHEMBL19670423 | 0.85 | TRPV3 (0.38) | PRKCIJAK2ABL1BCRCAMK2D | |
| SCHEMBL19670471 | 0.85 | POLQ (0.35) | ABL1BCRKARS1TRPV3IRAK4 | |
| SCHEMBL17618493 | 0.84 | DHFR (0.39) | DHFRFAAHPRKCIJAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |