Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670243 | 0.86 | KDM1A (0.38) | ALDH1A1SMN1; SMN2MAPTKDM4EMEN1 | |
| SCHEMBL19670242 | 0.78 | SLC27A1 (0.35) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL19670238 | 0.76 | TRPA1 (0.38) | SMN1; SMN2MAPTNPSR1KDM4EHPGD | |
| SCHEMBL19669970 | 0.76 | PIK3CA (0.36) | MTORALDH1A1SMN1; SMN2MAPTHTT | |
| SCHEMBL16776285 | 0.74 | NPC1 (0.36) | SMN1; SMN2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL17618763 | 0.73 | RAB9A (0.41) | ALDH1A1SMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL17618422 | 0.72 | RAB9A (0.40) | ALDH1A1SMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL17655381 | 0.72 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2KDM4EHPGDKMT2A | |
| SCHEMBL16775975 | 0.71 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL16775986 | 0.71 | SLC27A1 (0.36) | SMN1; SMN2RAB9AABL1JAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |