Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365758 | 0.90 | FGFR4 (0.36) | TRPV3PTGS2DYRK1ACHRNA7SCN10A | |
| SCHEMBL19670562 | 0.83 | ALOX15 (0.39) | TRPV3PTGS2DYRK1ACHRNA7ABL1 | |
| SCHEMBL19670548 | 0.82 | TRPM8 (0.38) | TRPV3PTGS2DYRK1ACHRNA7ABL1 | |
| SCHEMBL19706141 | 0.82 | P2RY1 (0.40) | NPC1RAB9ACYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL19365860 | 0.82 | CHRNA7 (0.36) | TRPV3DYRK1ACHRNA7ABL1 | |
| SCHEMBL19365405 | 0.82 | GABRA1 (0.39) | TRPV3PTGS2CHRNA7CYP3A4CYP2D6 | |
| SCHEMBL17618845 | 0.81 | NPC1 (0.34) | NPC1RAB9ACYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL19365787 | 0.81 | SCN10A (0.40) | TRPV3PTGS2DYRK1ACHRNA7SCN10A | |
| SCHEMBL19706290 | 0.81 | MAPT (0.39) | RAB9AALDH1A1TRPV3PTGS2HTT | |
| SCHEMBL19365548 | 0.80 | TRPV3 (0.37) | TRPV3PTGS2DYRK1ACHRNA7SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |