Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670548 | 0.91 | TRPM8 (0.38) | CHRNA7DYRK1AKDRFGFR1XPO1 | |
| SCHEMBL19365860 | 0.89 | CHRNA7 (0.36) | CHRNA7DYRK1AKDRFGFR1TRPV3 | |
| SCHEMBL19365405 | 0.87 | GABRA1 (0.39) | CHRNA7CYP3A4CYP2D6PTGS2TRPV3 | |
| SCHEMBL19365666 | 0.87 | HTR2C (0.41) | TSHRHSD17B10CYP3A4CYP2D6KDR | |
| SCHEMBL19365660 | 0.86 | DYRK1A (0.37) | CHRNA7DYRK1ACLK2GSK3BPIM1 | |
| SCHEMBL19365758 | 0.84 | FGFR4 (0.36) | CHRNA7DYRK1AKDRCSNK1DPTGS2 | |
| SCHEMBL19365548 | 0.84 | TRPV3 (0.37) | CHRNA7DYRK1ACLK2PTGS2TRPV3 | |
| SCHEMBL19365787 | 0.84 | SCN10A (0.40) | CHRNA7DYRK1APTGS2TRPV3ABL1 | |
| SCHEMBL19706290 | 0.83 | MAPT (0.39) | TSHRNPSR1PTGS2TRPV3MAPT | |
| SCHEMBL19670446 | 0.83 | NPC1 (0.36) | CHRNA7CYP3A4CYP2D6DYRK1APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |