Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365904 | 0.86 | MAPT (0.43) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL16775900 | 0.85 | LMNA (0.40) | MAPTLMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL17618420 | 0.84 | MAPT (0.44) | MAPTLMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL19365708 | 0.84 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1CA2CA9 | |
| SCHEMBL19365254 | 0.82 | HTR2C (0.47) | MAPTSMN1; SMN2TP53TSHRNPC1 | |
| SCHEMBL19365360 | 0.82 | CA2 (0.38) | MAPTLMNASMN1; SMN2HTTBRAF | |
| SCHEMBL19365568 | 0.82 | RHOA (0.50) | MAPTLMNAMAPK1HTTALDH1A1 | |
| SCHEMBL19365595 | 0.82 | MAPT (0.38) | MAPTLMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL19670464 | 0.81 | MAPT (0.40) | MAPTLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL20632111 | 0.81 | MAPT (0.46) | MAPTLMNASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |