Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670336 | 0.87 | MAPK9 (0.41) | CA2CA9GSK3BIDH1MAPK13 | |
| SCHEMBL17618876 | 0.85 | CA2 (0.39) | CA2CA9KMOGSK3BCTPS1 | |
| SCHEMBL19365904 | 0.83 | MAPT (0.43) | CA2CA9MEN1LMNAHTT | |
| SCHEMBL19670418 | 0.82 | MPL (0.42) | CA2CA9KMOKDM1AMAOA | |
| SCHEMBL19670583 | 0.82 | KMT2A (0.39) | CA2CA9KMOKDM1AMAOA | |
| SCHEMBL19365254 | 0.82 | HTR2C (0.47) | MEN1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL19365708 | 0.81 | MAPT (0.41) | CA2CA9LCKMAPK14KDM1A | |
| SCHEMBL19365368 | 0.81 | TRPA1 (0.38) | CA2CA9KMOKDM1AMAOA | |
| SCHEMBL19670246 | 0.81 | SCN9A (0.39) | CA2CA9KDM1AMAOAMAOB | |
| SCHEMBL19365596 | 0.81 | ADORA2A (0.39) | CA2CA9KMOKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |