Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 1/20 | 0.54 |
| ▸ | HSPA8 | P11142 | 3/20 | 0.46 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADA | P00813 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAPDH | P04406 | 1/20 | 0.41 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9810618 | 0.88 | HSPA5 (0.57) | HSPA8HSPA5PDE4APDE4BPDE4C | |
| SCHEMBL29328691 | 0.86 | ADORA2A (0.56) | HSPA8HSPA5PDE4APDE4BPDE4C | |
| SCHEMBL9617721 | 0.86 | HSPA5 (0.46) | AHCYHSPA8HSPA5RXFP1ADORA3 | |
| SCHEMBL29709122 | 0.86 | ADORA2A (0.56) | HSPA8HSPA5PDE4APDE4BPDE4C | |
| SCHEMBL23679560 | 0.83 | HSPA8 (0.45) | HSPA8HSPA5RXFP1ADORA3ADORA2A | |
| SCHEMBL9810713 | 0.83 | HSPA8 (0.45) | HSPA8HSPA5RXFP1ADORA3ADORA2A | |
| SCHEMBL30149930 | 0.81 | LMNA (0.38) | AHCYPDE4DRXFP1ALDH1A1LMNA | |
| SCHEMBL13835023 | 0.79 | ADORA3 (0.64) | AHCYHSPA8HSPA5PDE4APDE4B | |
| SCHEMBL19680323 | 0.79 | AHCY (0.55) | AHCYHSPA8HSPA5PDE4APDE4B | |
| SCHEMBL5982756 | 0.79 | ADORA3 (0.64) | AHCYHSPA8HSPA5PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464308-B1 | 8-CHLOROADENOSINE PHOSPHORAMIDATE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | NuCana plc (GB) | 2020-08-19 | — | — | EP | disclosed |
| WO-2017207989-A1 | ADENOSINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | NUCANA BIOMED LIMITED (GB) | 2017-12-07 | — | — | WO | disclosed |