Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28953170 | 0.95 | SIRT2 (0.38) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL22698603 | 0.94 | SIRT2 (0.35) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL20830828 | 0.92 | SIRT2 (0.34) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL16847844 | 0.91 | OPRM1 (0.33) | SIRT2SIRT1SIRT3FAP | |
| SCHEMBL17801960 | 0.91 | ITGB1 (0.34) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL17813693 | 0.90 | RAB9A (0.36) | SIRT2SIRT1SIRT3FAP | |
| SCHEMBL17650868 | 0.89 | HDAC3 (0.32) | SIRT2SIRT1FAP | |
| SCHEMBL21695294 | 0.89 | HDAC3 (0.37) | SIRT2SIRT1FAP | |
| SCHEMBL19803950 | 0.87 | HTR2A (0.37) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL16847982 | 0.87 | HTR2A (0.37) | SIRT2SIRT1SIRT3SIRT5FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | SIRT2 1003/4885SIRT1 2001/4885SIRT3 1344/4885 |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | SIRT2 1003/4885SIRT1 2001/4885SIRT3 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.