Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.32 |
| ▸ | FAP | Q12884 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17813693 | 0.93 | RAB9A (0.36) | RAB9ASIRT1OPRM1OPRD1OPRK1 | |
| SCHEMBL17650868 | 0.92 | HDAC3 (0.32) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL16847844 | 0.92 | OPRM1 (0.33) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL17801960 | 0.92 | ITGB1 (0.34) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL22698603 | 0.91 | SIRT2 (0.35) | SIRT1OPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL20830828 | 0.89 | SIRT2 (0.34) | SIRT1OPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL19683931 | 0.89 | SIRT2 (0.37) | SIRT1SIRT2FAP | |
| SCHEMBL21695307 | 0.89 | OPRM1 (0.34) | RAB9AOPRM1OPRD1OPRK1PSEN1 | |
| SCHEMBL28953170 | 0.88 | SIRT2 (0.38) | SIRT1SIRT2FAP | |
| SCHEMBL17803640 | 0.86 | PDF (0.38) | EHMT2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2020-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | H1-5, H1-4, CD47 | HDAC3 724/4885HDAC1 978/4885HDAC2 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.