Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.32 |
| ▸ | FAP | Q12884 | 3/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801960 | 0.94 | ITGB1 (0.34) | OPRM1OPRD1OPRK1ITGB1ITGA4 | |
| SCHEMBL17813693 | 0.93 | RAB9A (0.36) | OPRM1OPRD1OPRK1SIRT1FAP | |
| SCHEMBL22698603 | 0.92 | SIRT2 (0.35) | OPRM1OPRD1OPRK1SIRT1FAP | |
| SCHEMBL21695294 | 0.92 | HDAC3 (0.37) | OPRM1OPRD1OPRK1ITGB1ITGA4 | |
| SCHEMBL18332122 | 0.92 | PLG (0.38) | OPRM1OPRD1OPRK1HDAC3HDAC1 | |
| SCHEMBL17650868 | 0.92 | HDAC3 (0.32) | OPRM1OPRD1OPRK1ITGB1ITGA4 | |
| SCHEMBL21846594 | 0.91 | OPRM1 (0.32) | OPRM1OPRD1OPRK1HDAC3HDAC1 | |
| SCHEMBL20830828 | 0.91 | SIRT2 (0.34) | OPRM1OPRD1OPRK1SIRT1FAP | |
| SCHEMBL19683931 | 0.91 | SIRT2 (0.37) | SIRT1FAPSIRT2SIRT3 | |
| SCHEMBL28953170 | 0.90 | SIRT2 (0.38) | SIRT1FAPSIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024138128-A2 | CEREBLON DEGRADER CONJUGATES, AND USES THEREOF | GENENTECH, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230067037-A1 | CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE | GENENTECH, INC. (US) | 2023-03-02 | — | — | US | disclosed |
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |
| EP-3082875-B1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH INC (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20200222545-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2020-07-16 | — | — | US | disclosed |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-10632210-B2 | Peptidomimetic compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20200087297-A1 | QUATERNARY AMINE COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2020-02-11 | — | — | US | disclosed |
| WO-2016090040-A9 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2017-06-29 | — | — | WO | disclosed |
| US-20170002086-A1 | ANTIBODIES AND IMMUNOCONJUGATES | GENENTECH, INC. (US) | 2017-01-05 | — | — | US | disclosed |
| WO-2016205176-A1 | ANTIBODIES AND IMMUNOCONJUGATES | GENENTECH, INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| US-20160279260-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2016-09-29 | — | — | US | disclosed |
| US-20160279261-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2016-09-29 | — | — | US | disclosed |
| WO-2016090050-A1 | QUATERNARY AMINE COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016090040-A1 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016090038-A1 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2015095223-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015095227-A2 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200222545-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | OPRM1 603/4885OPRD1 1019/4885OPRK1 588/4885 |
| US-20170002086-A1 | ANTIBODIES AND IMMUNOCONJUGATES | FCGR3B, CD47, FCGR1A | OPRM1 4348/4885OPRD1 4148/4885OPRK1 3964/4885 |
| US-10632210-B2 | Peptidomimetic compounds and antibody-drug conjugates thereof | DNPEP, LNPEP, BCR | OPRM1 890/4885OPRD1 3991/4885OPRK1 3329/4885 |
| US-20230067037-A1 | CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE | ADRM1, SSB, FCER2 | OPRM1 3830/4885OPRD1 4182/4885OPRK1 3631/4885 |
| US-20160279260-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | DNPEP, LNPEP, BCR | OPRM1 890/4885OPRD1 3991/4885OPRK1 3329/4885 |
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | OPRM1 603/4885OPRD1 1019/4885OPRK1 588/4885 |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | OPRM1 603/4885OPRD1 1019/4885OPRK1 588/4885 |
| US-10556895-B2 | Quaternary amine compounds and antibody-drug conjugates thereof | H1-5, H1-4, CD47 | OPRM1 2448/4885OPRD1 4102/4885OPRK1 3424/4885 |
| US-20160279261-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | DNPEP, LNPEP, BCR | OPRM1 890/4885OPRD1 3991/4885OPRK1 3329/4885 |
| US-20200087297-A1 | QUATERNARY AMINE COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | H1-5, H1-4, CD47 | OPRM1 2448/4885OPRD1 4102/4885OPRK1 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.