Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20830828 | 0.94 | SIRT2 (0.34) | SIRT2SIRT1SIRT3SIRT5OPRM1 | |
| SCHEMBL19683931 | 0.94 | SIRT2 (0.37) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL28953170 | 0.93 | SIRT2 (0.38) | SIRT2SIRT1SIRT3SIRT5FAP | |
| SCHEMBL22698653 | 0.92 | SIRT2 (0.36) | SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL16847844 | 0.92 | OPRM1 (0.33) | SIRT2SIRT1SIRT3OPRM1OPRD1 | |
| SCHEMBL17801960 | 0.92 | ITGB1 (0.34) | SIRT2SIRT1SIRT3SIRT5OPRM1 | |
| SCHEMBL17813693 | 0.91 | RAB9A (0.36) | SIRT2SIRT1SIRT3OPRM1OPRD1 | |
| SCHEMBL21695294 | 0.91 | HDAC3 (0.37) | SIRT2SIRT1OPRM1OPRD1OPRK1 | |
| SCHEMBL17650868 | 0.91 | HDAC3 (0.32) | SIRT2SIRT1OPRM1OPRD1OPRK1 | |
| SCHEMBL17803640 | 0.87 | PDF (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458101-B1 | PROTAC ANTIBODY CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2020-12-30 | — | — | EP | disclosed |
| EP-3082875-B1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH INC (US) | 2020-11-25 | — | — | EP | disclosed |