Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | CASR | P41180 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2703655 | 1.00 | PDE2A (0.58) | PDE2ADRD2CASRGAALMNA | |
| SCHEMBL5827084 | 1.00 | PDE2A (0.58) | PDE2ADRD2CASRGAALMNA | |
| SCHEMBL10039780 | 0.89 | PDE2A (0.55) | PDE2AGAALMNA | |
| SCHEMBL10039649 | 0.88 | PYGL (0.53) | PDE2AGAALMNA | |
| SCHEMBL10039604 | 0.86 | MEN1 (0.56) | PDE2AGAALMNAKDM4EALDH1A1 | |
| SCHEMBL10039653 | 0.86 | DRD2 (0.58) | DRD2GAALMNATAS1R3TAS1R1 | |
| SCHEMBL10039781 | 0.85 | PDE2A (0.49) | PDE2AGAALMNA | |
| SCHEMBL10039635 | 0.85 | DRD2 (0.52) | DRD2GAALMNATAS1R3TAS1R1 | |
| SCHEMBL10039633 | 0.85 | KMT2A (0.72) | PDE2AGAALMNAKDM4E | |
| SCHEMBL19709262 | 0.85 | KDM4E (0.56) | DRD2GAALMNATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10775375-B2 | Methods for identifying modulators of calcium-sensing receptors | MARS, INCORPORATED (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190324031-A1 | METHODS FOR IDENTIFYING MODULATORS OF CALCIUM-SENSING RECEPTORS | MARS, INCORPORATED (US) | 2019-10-24 | — | — | US | disclosed |
| US-10393740-B2 | Methods for identifying modulators of calcium-sensing receptors | MARS, INCORPORATED (US) | 2019-08-27 | — | — | US | disclosed |
| US-20170356907-A1 | METHODS FOR IDENTIFYING MODULATORS OF CALCIUM-SENSING RECEPTORS | MARS, INCORPORATED (US) | 2017-12-14 | — | — | US | disclosed |