Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL27473772 | 0.83 | TSHR (0.80) | TSHRTP53SRD5A2CA1CA2 | |
| SCHEMBL2206586 | 0.83 | HTT (0.62) | TSHRSMN1; SMN2HTT | |
| SCHEMBL2304015 | 0.81 | PARP1 (0.55) | TSHRCA1CA2SMN1; SMN2ALDH1A1 | |
| Terephthalic Acid SCHEMBL27575972 | 0.80 | TSHR (0.75) | TSHRTP53SRD5A2CA1CA2 | |
| Paraben SCHEMBL9755598 | 0.80 | CA2 (0.76) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL11858116 | 0.80 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27400233 | 0.80 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2511919 | 0.80 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL175823 | 0.80 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL5053781 | 0.80 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144188-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | ANTIBE THERAPEUTICS INC. (CA) | 2011-06-16 | — | — | US | claimed |
| US-7666907-B2 | Salts of trimebutine and N-desmethyl trimebutine | ANTIBE THERAPEUTICS INC. (CA) | 2010-02-23 | — | — | US | claimed |
| CN-101489986-A | Salts of trimebutine and N-desmethyl trimebutine | ANTIBE THERAPEUTICS INC (CA) | 2009-07-22 | — | — | CN | claimed |
| EP-2024323-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | Antibe Therapeutics Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007140611-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | ANTIBE THERAPEUTICS INC. (CA) | 2007-12-13 | — | — | WO | claimed |
| US-20070275905-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | ANTIBE THERAPEUTICS INC. (CA) | 2007-11-29 | — | — | US | claimed |
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| EP-0128097-B1 | IMMUNOSTIUMULATING DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1988-01-13 | — | — | EP | claimed |
| US-9242009-B2 | Compositions and methods to treat neurodegenerative diseases | THE GENERAL HOSPITAL CORPORATION (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150209438-A1 | COMPOSITIONS AND METHODS TO TREAT NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION | 2015-07-30 | — | — | US | disclosed |
| US-20150057316-A1 | NOVEL SULFONATE-BASED TRIMEBUTINE SALTS | GICARE PHARMA INC. (CA) | 2015-02-26 | — | — | US | disclosed |
| EP-2825523-A1 | NOVEL SULFONATE-BASED TRIMEBUTINE SALTS | Gicare Pharma Inc. (CA) | 2015-01-21 | — | — | EP | disclosed |
| WO-2014015047-A1 | COMPOSITIONS AND METHODS TO TREAT NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-01-23 | — | — | WO | disclosed |
| US-20070275905-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | ANTIBE THERAPEUTICS INC. (CA) | 2007-11-29 | — | — | US | disclosed |
| US-5614520-A | 2-arylthiazole derivatives and pharmaceutical composition thereof | TEIJIN LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0513379-B1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LTD (JP) | 1996-09-11 | — | — | EP | disclosed |
| EP-0513379-A1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LIMITED (JP) | 1992-11-19 | — | — | EP | disclosed |
| US-4801578-A | Muramylpeptide-glycoprotein immunostimulant derivatives, their preparation and their use in medication | Establishment Public dit Centre National de la Recherche Scientifique (CNRS) (FR) | 1989-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057316-A1 | NOVEL SULFONATE-BASED TRIMEBUTINE SALTS | TBK1, SI, TRIM59 | TSHR 4475/4885TP53 4481/4885SRD5A2 3899/4885 |
| US-20110144188-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | SI, VIP, TRIM59 | TSHR 4727/4885TP53 4144/4885SRD5A2 3777/4885 |
| US-20150209438-A1 | COMPOSITIONS AND METHODS TO TREAT NEURODEGENERATIVE DISEASES | PSEN2, SNCA, PSEN1 | TSHR 4818/4885TP53 2918/4885SRD5A2 3950/4885 |
| US-20070275905-A1 | SALTS OF TRIMEBUTINE AND N-DESMETHYL TRIMEBUTINE | SI, VIP, TRIM59 | TSHR 4727/4885TP53 4144/4885SRD5A2 3777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.