Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.47 |
| ▸ | GABRP | O00591 | 6/20 | 0.47 |
| ▸ | GABRD | O14764 | 6/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.47 |
| ▸ | GABRE | P78334 | 6/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019601 | 0.90 | CYP1A2 (0.59) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL1644521 | 0.83 | POLB (0.70) | CYP1A2POLBLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1644378 | 0.83 | CYP1A2 (0.52) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL14072103 | 0.80 | ESR1 (0.50) | LMNAALDH1A1NPC1MAPTKDM4E | |
| SCHEMBL8883054 | 0.80 | POLB (0.49) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL600789 | 0.80 | GABRA1 (0.49) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL991765 | 0.80 | POLB (0.49) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL31285451 | 0.80 | GABRA1 (0.49) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL7999648 | 0.80 | SIRT6 (0.52) | CYP1A2POLBGABRA1GABRG2GABRB3 | |
| SCHEMBL30986210 | 0.80 | SIRT6 (0.52) | CYP1A2POLBGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272626-A1 | PYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-09-22 | — | — | US | disclosed |
| EP-2917211-A1 | PYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-09-16 | — | — | EP | disclosed |
| CN-104768950-A | Pyrazine derivatives | HOFFMANN LA ROCHE | 2015-07-08 | — | — | CN | disclosed |
| WO-2014072257-A1 | PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-15 | — | — | WO | disclosed |
| EP-2321282-B1 | NEW BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2013-03-27 | — | — | EP | disclosed |
| US-8088930-B2 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | CYP3A7, ECI1, CYP2B6 | CYP1A2 54/4885POLB 3169/4885GABRA1 73/4885 |
| US-20160272626-A1 | PYRAZINE DERIVATIVES | HCRTR2, PER2, HCRTR1 | CYP1A2 37/4885POLB 1942/4885GABRA1 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.