Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.57 |
| ▸ | ABAT | P80404 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.57 |
| ▸ | CXCL12 | P48061 | 4/20 | 0.55 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359491 | 0.85 | ALDH1A1 (0.68) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL972755 | 0.83 | ALDH1A1 (0.76) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL9072185 | 0.83 | ALDH1A1 (0.66) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL1515911 | 0.82 | ALDH1A1 (0.69) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL2890759 | 0.82 | ALDH1A1 (0.73) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL27430789 | 0.81 | FDPS (0.51) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL17782945 | 0.81 | ALDH1A1 (0.72) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL1098158 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL14323012 | 0.81 | ALDH1A1 (0.71) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL1515863 | 0.80 | ALDH1A1 (0.65) | ALDH1A1TRIM24HPGDALDH5A1ABAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046657-B2 | Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-06-29 | — | — | US | disclosed |
| US-20200181093-A1 | Pyrimidinone Derivatives and Uses Thereof to Neutralize the Biological Activity of Chemokines | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2020-06-11 | — | — | US | disclosed |
| WO-2018011376-A1 | PYRIMIDINONE DERIVATIVES AND USES THEREOF TO NEUTRALIZE THE BIOLOGICAL ACTIVITY OF CHEMOKINES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - (FR) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181093-A1 | Pyrimidinone Derivatives and Uses Thereof to Neutralize the Biological Activity of Chemokines | CCL5, CXCR3, CXCL10 | ALDH1A1 1436/4885TRIM24 2777/4885HPGD 423/4885 |
| US-11046657-B2 | Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines | CCL5, CXCR3, CXCL10 | ALDH1A1 1436/4885TRIM24 2777/4885HPGD 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.