Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979905 | 0.89 | P2RX7 (0.43) | KCNA3SLC6A2SLC6A4SLC6A3P2RX7 | |
| SCHEMBL10150960 | 0.82 | PDE10A (0.42) | SMN1; SMN2P2RX7TP53MEN1KMT2A | |
| SCHEMBL2015522 | 0.79 | BCL2 (0.42) | ALDH1A1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL10150652 | 0.75 | THRB (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1973915 | 0.75 | PPARG (0.37) | — | |
| SCHEMBL2013388 | 0.73 | THRB (0.39) | ALDH1A1 | |
| SCHEMBL10150590 | 0.72 | PDE10A (0.42) | GAAKMT2A | |
| SCHEMBL2010877 | 0.71 | L3MBTL1 (0.48) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1975060 | 0.69 | PPARG (0.40) | ALDH1A1SMN1; SMN2NPSR1TP53MEN1 | |
| SCHEMBL1973564 | 0.67 | TACR3 (0.46) | ALDH1A1SMN1; SMN2NPSR1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144164-A1 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144164-A1 | Pyridone derivatives as NK3 antagonists | KCNK3, GRIK3, KCND3 | KCNA3 4/4885SLC6A2 218/4885SLC6A4 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.