Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979576 | 0.87 | HTR2B (0.50) | MTNR1AMTNR1BALDH1A1HTR2BNOTUM | |
| SCHEMBL1976609 | 0.85 | MTNR1A (0.40) | MTNR1AMTNR1BHTR2BPARP1NOTUM | |
| SCHEMBL1976442 | 0.85 | SPR (0.46) | MTNR1AMTNR1BALDH1A1HTR2BPARP1 | |
| SCHEMBL1975895 | 0.84 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1HTR2BPARP1 | |
| SCHEMBL1977036 | 0.84 | MTNR1A (0.43) | MTNR1AMTNR1BHTR2BPARP1 | |
| SCHEMBL1976202 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BUSP2ALDH1A1HTR2B | |
| SCHEMBL1983046 | 0.81 | HTR1A (0.37) | MTNR1AMTNR1BHTR2BPARP1HTR1A | |
| SCHEMBL31105573 | 0.79 | MPO (0.45) | MTNR1AHTR2BPARP1HTR1AHTR1D | |
| SCHEMBL1980304 | 0.78 | HTR2A (0.51) | HTR2BPARP1HTR1AHTR1DHTR2A | |
| SCHEMBL2638570 | 0.77 | GAA (0.41) | HTR2BPARP1HTR1AHTR1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | claimed |
| JP-2011529477-A | — | — | 2011-12-08 | — | — | JP | claimed |
| EP-2350088-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2011-08-03 | — | — | EP | claimed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | claimed |
| WO-2010012789-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL S. A. (ES) | 2010-02-04 | — | — | WO | claimed |
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | disclosed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | MTNR1A, MTNR1B, ADORA2A | MTNR1A 1/4885MTNR1B 2/4885USP2 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.