Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31105573 | 0.83 | MPO (0.45) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL2638570 | 0.82 | GAA (0.41) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL1983046 | 0.82 | HTR1A (0.37) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL1979576 | 0.80 | HTR2B (0.50) | HTR2BHTR1AMPOKMT2ACYP1A2 | |
| SCHEMBL1976609 | 0.78 | MTNR1A (0.40) | HTR2BPARP1 | |
| SCHEMBL1976442 | 0.78 | SPR (0.46) | HTR2BPARP1KMT2ACYP3A4 | |
| SCHEMBL1978688 | 0.78 | MTNR1A (0.44) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL31105757 | 0.76 | HTR1A (0.44) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL2639532 | 0.75 | HTR2A (0.43) | HTR2AHTR2CHTR2BHTR1DHTR1A | |
| SCHEMBL31105598 | 0.74 | MPO (0.46) | HTR2AHTR2CHTR2BHTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | claimed |
| JP-2011529477-A | — | — | 2011-12-08 | — | — | JP | claimed |
| WO-2010012789-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL S. A. (ES) | 2010-02-04 | — | — | WO | claimed |
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | disclosed |
| EP-2350088-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2011-08-03 | — | — | EP | disclosed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | disclosed |
| WO-2010012789-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL S. A. (ES) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | MTNR1A, MTNR1B, ADORA2A | HTR2A 40/4885HTR2C 59/4885HTR2B 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.