Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 15/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1976609 | 0.89 | MTNR1A (0.40) | HTR2BMTNR1AMTNR1BNOTUMSPR | |
| SCHEMBL1976442 | 0.89 | SPR (0.46) | HTR2BMTNR1AMTNR1BNOTUMCYP3A4 | |
| SCHEMBL1977036 | 0.88 | MTNR1A (0.43) | HTR2BMTNR1AMTNR1BSPRMEN1 | |
| SCHEMBL1978688 | 0.87 | MTNR1A (0.44) | HTR2BMTNR1AMTNR1BNOTUMALDH1A1 | |
| SCHEMBL1975895 | 0.86 | MTNR1A (0.53) | HTR2BMTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL31105573 | 0.83 | MPO (0.45) | HTR2BMTNR1AMPOHTR1ASLC6A4 | |
| SCHEMBL1983046 | 0.82 | HTR1A (0.37) | HTR2BMTNR1AMTNR1BHTR1ASLC6A4 | |
| SCHEMBL1981297 | 0.81 | HTR2B (0.48) | HTR2BMTNR1AMTNR1BNOTUMCYP1A2 | |
| SCHEMBL1980304 | 0.80 | HTR2A (0.51) | HTR2BCYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL2638570 | 0.78 | GAA (0.41) | HTR2BNPSR1MPOHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | claimed |
| JP-2011529477-A | — | — | 2011-12-08 | — | — | JP | claimed |
| EP-2350088-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2011-08-03 | — | — | EP | claimed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | claimed |
| WO-2010012789-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL S. A. (ES) | 2010-02-04 | — | — | WO | claimed |
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | disclosed |
| EP-2350088-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2011-08-03 | — | — | EP | disclosed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | disclosed |
| WO-2010012789-A1 | 1,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL S. A. (ES) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | MTNR1A, MTNR1B, ADORA2A | HTR2B 133/4885MTNR1A 1/4885MTNR1B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.