Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16446289 | 0.85 | ALDH1A1 (0.32) | ALDH1A1ALOX15TSHRLMNACYP1A2 | |
| SCHEMBL16446341 | 0.82 | LMNA (0.30) | LMNA | |
| SCHEMBL11157714 | 0.79 | KDM4E (0.41) | ALDH1A1 | |
| SCHEMBL11862558 | 0.77 | TYMP (0.38) | ALDH1A1ALOX15TSHRLMNA | |
| SCHEMBL7981865 | 0.77 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHR | |
| SCHEMBL12481375 | 0.76 | ALDH1A1 (0.35) | ALDH1A1ALOX15TSHR | |
| SCHEMBL4848080 | 0.75 | L3MBTL1 (0.38) | ALDH1A1LMNACYP1A2 | |
| SCHEMBL16511139 | 0.75 | ALDH1A1 (0.30) | ALDH1A1ALOX15TSHR | |
| SCHEMBL16511129 | 0.75 | ALDH1A1 (0.30) | ALDH1A1ALOX15TSHR | |
| SCHEMBL5556067 | 0.75 | ESR1 (0.35) | ALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315739-B | Pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-109415369-B | Fused pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-109311877-B | Fused pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2021-05-28 | — | — | CN | disclosed |
| EP-3481829-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-04-07 | — | — | EP | disclosed |
| EP-3484884-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-20200291032-A1 | PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-09-17 | — | — | US | disclosed |
| US-10730881-B2 | Fused pyrimidine derivatives | HOFFMANN-LA ROCHE, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| CN-111315739-A | Pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2020-06-19 | — | — | CN | disclosed |
| US-10669276-B2 | Fused pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190256517-A1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-08-22 | — | — | US | disclosed |
| US-20190177329-A1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-06-13 | — | — | US | disclosed |
| WO-2019101984-A1 | PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2019-05-31 | — | — | WO | disclosed |
| CN-109415369-A | Fused pyrimidine derivative | 豪夫迈·罗氏有限公司 | 2019-03-01 | — | — | CN | disclosed |
| WO-2018011164-A1 | FUSED PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291032-A1 | PYRIMIDINE DERIVATIVES | TYMS, DPYD, TYMP | ALDH1A1 652/4885ALOX15 3464/4885TSHR 2653/4885 |
| US-10730881-B2 | Fused pyrimidine derivatives | APP, UPF1, PSEN1 | ALDH1A1 2365/4885ALOX15 423/4885TSHR 3323/4885 |
| US-20190256517-A1 | FUSED PYRIMIDINE DERIVATIVES | C9, APP, HPGDS | ALDH1A1 3005/4885ALOX15 204/4885TSHR 2509/4885 |
| US-10669276-B2 | Fused pyrimidine derivatives | APP, APOB, C9 | ALDH1A1 3117/4885ALOX15 298/4885TSHR 2516/4885 |
| US-20190177329-A1 | FUSED PYRIMIDINE DERIVATIVES | APP, UPF1, PSEN1 | ALDH1A1 2365/4885ALOX15 423/4885TSHR 3323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.